Question 1
Match the following:  

· Question 2
An investigator wants to assess whether the use of a specific medication given to infants born prematurely is associated with developmental delay. Fifty infants who were given the medication and fifty comparison infants who were also born prematurely but not given the medication will be selected for the analysis. Each infant will undergo extensive testing at age 2 for various aspects of development. Identify the type of study proposed and indicate its specific strengths and weaknesses.
Type of study: Strengths: Weaknessess:


· Question 3
In 1940, 2,000 women working in a factory were recruited into a study. Half of the women worked in manufacturing and half in administrative offices. The incidence of bone cancer through 1970 among the 1,000 women working in manufacturing was compared with that of 1,000 women working in administrative offices. Thirty of the women in manufacturing developed bone cancer as compared to 9 of the women in administrative offices. This study is an example of a:
___ __ study


· Question 4
A clinical trial is conducted to evaluate the effectiveness of a new drug to prevent preterm delivery. A total of n=250 pregnant women agree to participate and are randomly assigned to receive either the new drug or a placebo and followed through the course of pregnancy. Among 125 women receiving the new drug, 24 deliver preterm and among 125 women receiving the placebo, 38 deliver preterm. Construct a 95% confidence interval for the difference in proportions of women who deliver preterm.
1. Upper Limit CI= 2. Lower Limt CI =


· Question 5
A study is designed to investigate whether there is a difference in response to various treatments in patients with rheumatoid arthritis. The outcome is patient’s selfreported effect of treatment. The data are shown below. Is there a statistically significant difference in the proportions of patients who show improvement between treatments 1 and 2. Apply the test at a 5% level of significance.
1. Critical value: 2. Computed statistic: 3. Based on comparing the computed statistics to the critical value which of the following is (are) true? a. There is significant evidence, alpha=0.05, to show that there is a difference in the proportions of patients who show improvement between treatments 1 and 2. b. There is not significant evidence, alpha=0.05, to show that there is a difference in the proportions of patients who show improvement between treatments 1 and 2. c. There is significant evidence, alpha=0.05, to show that there is a no difference in the proportions of patients who show improvement between treatments 1 and 2. d. a and c.




· Question 6
The following data were collected in a clinical trial to compare a new drug to a placebo for its effectiveness in lowering total serum cholesterol. Generate a 95% confidence interval for theproportion of all patients with total cholesterol < 200.
1. Upper limit of CI: 2. Lower limit of CI: 3. How many patients would be required to ensure that a 95% confidence interval has a margin of error not exceeding 5%? n= ____314_____


· Question 7
Peak expiratory flow (PEF) is a measure of a patient’s ability to expel air from the lungs. Patients with asthma or other respiratory conditions often have restricted PEF. The mean PEF for children free of asthma is 306. An investigator wants to test whether children with chronic bronchitis have restricted PEF. A sample of 40 children with chronic bronchitis are studied and their mean PEF is 279 with a standard deviation of 71. Is there statistical evidence of a lower mean PEF in children with chronic bronchitis? Apply the appropriate test at alpha=0.05.
1. Critical z value: 2. Computed z:
3. Based on comparing the critical z value to the computed z value which of the following is (are) true? a. There is statistically significant evidence at alpha=0.05 to show a lower mean PEF in children with chronic bronchitis? b. There is not statistically significant evidence at alpha=0.05 to show a lower mean PEF in children with chronic bronchitis? c. There are not enough data points to reach a conclusion. d. b and c. 

· Question 8
Average adult Americans are about one inch taller, but nearly a whopping 25 pounds heavier than they were in 1960, according to a new report from the Centers for Disease Control and Prevention (CDC). The bad news, says CDC is that average BMI (body mass index, a weightforheight formula used to measure obesity) has increased among adults from approximately 25 in 1960 to 28 in 2002.” Boston is considered one of America’s healthiest cities – is the weight gain since 1960 similar in Boston? A sample of n=25 adults suggested a mean increase of 17 pounds with a standard deviation of 8.6 pounds. Is Boston statistically significantly different in terms of weight gain since 1960? Apply the appropriate test at a 5% level of significance.
1. Critical t value: +/
2. Computed statistic:
3. Based on comparing the computed statistic to the critical value which of the following is (are) true? a. There is significant evidence, alpha=0.05, that the BMI for Boston residents is significantly different than 25. b. There is not significant evidence, alpha=0.05, that the BMI for Boston residents is significantly different than 25. c. Statistically speaking the difference between the BMI for Boston residents and a BMI of 25 . is 0. d. b and c. 

· Question 9
The following table was presented in an article summarizing a study to compare a new drug to a standard drug and to a placebo.
1. Which, if any, baseline characteristics are significantly different (at the 0.05 level of significance) between treatment groups? a. Disease Stage b. Annual Income c. % with Insurance d. Age e. a and c f. b and d
*Table entries and Mean (SD) or % 

· Question 10
A randomized controlled trial is run to evaluate the effectiveness of a new drug for asthma in children. A total of 250 children are randomized to either the new drug or placebo (125 per group). There are 63 boys assigned to the new drug group and 58 boys assigned to the placebo. Is there a statistically significant difference in the proportions of boys assigned to the treatments? Apply the appropriate test at a 5% level of significance.
1. Critical value = a. There is significant evidence, alpha=0.05, that there is a difference in the proportions of boys assigned to the treatments. b. There is not significant evidence, alpha=0.05, that there is a difference in the proportions of boys assigned to the treatments. c. Statistically speaking the difference in the proportions of boys assigned to the treatments is 0. d. b and c. 

· Question 11
An investigator conducts a study to investigate whether there is a difference in mean PEF in children with chronic bronchitis as compared to those without. Data on PEF are collected and summarized below. Based on the data, is there statistical evidence of a lower mean PEF in children with chronic bronchitis as compared to those without? Apply the two sample t test at alpha=0.05.
1. Z 95% Confidence Interval:
2. Upper Limit 95% CI: 3. Lower Limit 95% CI: 4. Based on comparing the critical the upper and lower limits of the confidence interval for the mean PEF for children with No Chronic Bronchitis to the mean PEF for children With Bronchitis which of the following is (are) true. (4 points) a. There is statistical evidence of a lower mean PEF in children with chronic bronchitis as compared to those without. b. There is not statistical evidence of a lower mean PEF in children with chronic bronchitis as compared to those without. c. The confidence interval contains the mean PEF for the No Chronic Bronchitis group. d. a and c.


· Question 12
The table below summarizes baseline characteristics on patients participating in a clinical trial.
1. Which, if any, baseline characteristics are significantly different (at the 0.05 level of significance) between treatment groups? (10 points) a. Age b. Total Cholesterol c. Diabetes d. % Female e. a and b f. c and d


· Question 13
A small pilot study is conducted to investigate the effect of a nutritional supplement on total body weight. Six participants agree to take the nutritional supplement. To assess its effect on body weight, weights are measured before starting the supplementation and then after 6 weeks. The data are shown below. Is there a significant increase in body weight following supplementation? Use a paired ttest at a 5% level of significance.
1. df=__5___ 2. Critical value: As this is a left tailed test so critical value = t(0.05,df = 5) = 2.015; From ttable 3. Computed statistic: As we can see that this is a paired sample test so we need to find out the difference and the mean and standard deviation of the differences. The differences are 2, 3, 4, 5, 1 and 1 which is giving mean = 0.6667 and sample standard deviation = 3.2660. So test statistic = = 0.50 4. Based on comparing the computed statistic to the critical value which of the following is (are) true? a. There is significant evidence, alpha=0.05, to show that body weight increased following supplementation? b. There is not significant evidence, alpha=0.05, to show that body weight increased following supplementation? c. Statistically speaking the difference in initial weights and weights after 6 weeks is 0. d. b and c.


· Question 14
The graph below shows what kind of relationship between the independent and dependent variables:
The graph shows a positive relationship between the independent and dependent variables.


· Question 15 (IGNORE THIS QUESTION)
Which of the following is NOT true concerning scatterplots?  

· Question 16
Examine the above graphs below and answer the following questions.
1. Which of the above graphs indicates a negative relationship between the graphed variables? (Include all that are negative) D, E and F
2. On which axis is the dependent variable graphed? 3. Which of the above graphs indicated the highest correlation?




· Question 17
The following data were collected in a study relating hypertensive status measured at baseline to incident stroke over 5 years.
1. Compute the cumulative incidence of stroke in the study.
Cumulative Incidence =
2. Compute the cumulative incidence of stroke in patients classified as hypertensive at baseline.
Cumulative Incidence Hypertensive =
3. Compute the cumulative incidence of stroke in patients free of hypertension at baseline.
Cumulative Incidence Not Hypertensive =
4. Compute the risk difference of stroke in patients with hypertension as compared to patients free of hypertension.
Risk Difference =
5. Compute the relative risk of stroke in patients with hypertension as compared to patients free of hypertension.
Relative Risk =
6. Compute the population attributable risk of stroke due to hypertension.
PAR =


· Question 18
The survival curve below depicts survival times and rates for a particular cancer diagnosed at various stages of progression.
1. At what time (to the nearest year) does 12 year survival appear certain for Stages II cancer? 2. For Stage I cancer what is the minimum survival time (to the nearest year)? 1 year 3. What is the median survival time for Stage IV cancer (to the nearest year)? 1 year 

· Question 19
In a 10 year study of CAD some patients were not followed for a total of 10 years. Some suffered events (i.e., developed coronary artery disease during the course of followup) while others dropped out of the study. The following table displays the total number of personyears of followup in each group.
1. Compute the incidence rate of coronary artery disease in patients receiving the new medication.
Incidence Rate New Medication = per 1,000 person years.
2. Compute the incidence rate of coronary artery disease in patients receiving placebo.
Incidence Rate Placebo = per 1,000 person years.


· Question 20
A small cohort study is conducted in 13 patients with an aggressive cellular disorder linked to cancer. The clinical courses of the patients are depicted graphically below.
1. Compute the prevalence of cancer at 12 months.
Prevalence = 2. Compute the cumulative incidence of cancer at 12 months.
Cumulative Incidence 12 Months = 3. Compute the incidence rate (per month) of cancer.
4. Compute the incidence rate (per month) of death.
Incidence Rate = . 
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